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Even though we realize the potential for missing Individuals serosurvey topics who may have sought care elsewhere as opposed to study facility, the analyze facility was the main healthcare service provider covering the analyze place. Also, we did not validate these self-described fever episodes with health care charts, at facilities in addition to the one particular less than our surveillance review. This serosurvey was not made to carefully watch clinical situation in the catchment area populace. Consequently, we do not claim to obtain evaluated all achievable dengue circumstances with fever within the longitudinal serosurvey cohort for their medical results. Moreover, given that we determined seroconversion only Amongst the 518 topics without the need of prior exposure to dengue, we do not make an effort to affiliate self-claimed dengue episodes with seroconversion.

All round, our knowledge guidance that there's superior load of dengue Within this area. Although there are actually discrepancies regarding the time period, analyze place, laboratory affirmation procedures, and age grouping, the seropositivity estimates (determined by PRNT50) within the Sanofi’s Section IIB and Phase III dengue vaccine trials in Ratchaburi had been similar to our conclusions, all over 70%, Specifically amongst more mature children (9–seventeen several years in the Sanofi’s trial data).

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Cascade of serostatus data detected by oblique ELISA amongst seronegative people at enrollment.

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With regard to age, quite a few experiments documented transforming epidemiologic patterns where by a shift in age is noticed with a higher Affiliation of dengue hemorrhagic fever with older ages [10,eleven].

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